EBI3 (NM_005755) Human Recombinant Protein
$460.00
5 Days*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | CHO |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-His |
| Predicted MW | 50 kDa |
| Concentration | lot specific |
| Purity | >95%, as determined by Coomassie stained SDS-PAGE. |
| Buffer | 0.22 µm filtered protein solution is in 20 mM HEPES, 300 mM NaCl, 2 mM CHAPS, pH 7.2 |
| Bioactivity | The ED50 is 60 - 90 ng/ml, corresponding to a specific activity of 1.1 - 1.7 x 10^4 units/mg, determined by mouse splenocytes IL-2 inhibition induced by hIL-27 in mouse splenocytes activated with anti-CD3 and anti-CD28 antibodies. Co-immunoprecipitation (PMID: 27019190) |
| Endotoxin | Less than 0.01 ng per µg protein as determined by the LAL method |
| Storage | Store at -80°C. |
| Stability | Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_005746 |
| Locus ID | 10148 |
| UniProt ID | Q14213 |
| Cytogenetics | 19p13.3 |
| RefSeq Size | 1149 |
| RefSeq ORF | 687 |
| Synonyms | IL-27B; IL27B; IL35B |
| Summary | This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. provided by RefSeq, Sep 2008 |
| Protein Categories | Cytokines, Secreated Proteins |
| Protein Families | Druggable Genome, Secreted Protein |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "EBI3" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| LC417095 | Lyophilized EBI3 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY417095 | Transient overexpression lysate of Epstein-Barr virus induced 3 (EBI3) (as WB positive control) | 100 ug |
$436.00
|
|
| TP761619 | Purified recombinant protein of Human Epstein-Barr virus induced 3 (EBI3), full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug | 50 ug |
$270.00
|
|
Citations
A novel IL-23p19/Ebi3 (IL-39) cytokine mediates inflammation in Lupus-like mice
Wang, Wei, Xiao et al
Eur. J. Immunol. (2016)
Wang, Wei, Xiao et al
Eur. J. Immunol. (2016)
Cited by 175
AI Summary: OriGene’s human IL-27/IL-35 Ebi3 subunit and human IL-23 p19 subunit proteins were used in immunoprecipitation and Western blot analyses to characterize the novel IL-39 cytokine described in this study.
Snippet: This study was approved by the Animal Ethics Committee of the Beijing Institute of Basic Medical Sciences. Immunoprecipitation and Western blot analysis. A 5 ng/mL human IL-27/IL-35 Ebi3 subunit (Origene) and 5 ng/mL human IL-23 p19 subunit (Origene) were mixed ... Cite SaveSaving
Showing 1-1 of 1 papers.
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