EGF (NM_001963) Human Recombinant Protein

CAT#: TP723821

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Purified recombinant protein of Human epidermal growth factor (EGF), transcript variant 1



  View other "EGF" proteins (6)

USD 150.00


Availability*
5 Days

Size
    • 100 ug


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Specifications

Product Data
Description Purified recombinant protein of Human epidermal growth factor (EGF), transcript variant 1
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence Human EGF, 54 the region of Asn971-Arg1023 with an N-terminal Met, from gene Accession# NM_001963
Tag Tag Free
Predicted MW 6 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity >98%, as determined by Coomassie stained SDS-PAGE.
Buffer 1 x PBS
Bioactivity The ED50 is 1-2 ng/ml, corresponding to a specific activity 5x10^5 - 1x10^6 units/mg, determined by a dose-dependent inhibition on A431 cells proliferation.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method
Storage Store at -80°C.
Stability Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Reference Data
RefSeq NP_001954
Locus ID 1950
Refseq Size 5600
Cytogenetics 4q25
Refseq ORF 3621
Synonyms HOMG4; URG
Summary This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Protein Families Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transmembrane
Protein Pathways Bladder cancer, Cytokine-cytokine receptor interaction, Endocytosis, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton

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Other Versions

Frequently bought together (1)
EGF mouse monoclonal antibody,clone OTI2F9
    • 100 ul

USD 379.00

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