IL7 (NM_000880) Human Recombinant Protein

CAT#: TP723791

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Purified recombinant protein of Human interleukin 7 (IL7), transcript variant 1


 Product Datasheet for 'TP723791'

  View other "IL7" proteins (8)

USD 255.00


Availability*
2 Weeks

Size
    • 10 ug


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Specifications

Product Data
Description Purified recombinant protein of Human interleukin 7 (IL7), transcript variant 1
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence Human IL-7, the region of Asp26-His177, from gene Accession# NM_000880.3
Tag Tag Free
Predicted MW 18.8 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity >98%, as determined by Coomassie stained SDS-PAGE.
Buffer 1 x PBS
Bioactivity The ED50 is 1 - 5 ng/ml, corresponding to a specific activity of 0.20 - 1.0 x 10^6 units/mg, determined by PHA-activated human PBL proliferation induced by human IL-7 in a dose dependent manner.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method.
Reference Data
RefSeq NP_000871
Locus ID 3574
Refseq Size 2089
Cytogenetics 8q21.13
Refseq ORF 531
Synonyms IL-7
Summary The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed. [provided by RefSeq, Dec 2010]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

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Other Versions

Frequently bought together (1)
Rabbit polyclonal IL-7 antibody Biotin Conjugated
    • 100 ug

USD 515.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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