Il33 (NM_133775) Mouse Recombinant Protein

CAT#: TP723779

Purified recombinant protein of Mouse interleukin 33 (Il33), transcript variant 2

Product Images

Specifications

Product Data

• Species: Mouse
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Mouse IL-33, the region of Ser109-Ile266, from gene Accession# NM_133775
• Tag: Tag Free
• Predicted MW: 17.6 kDa
• Concentration: lot specific
• Purity: >98%, as determined by Coomassie stained SDS-PAGE.
• Buffer: 20 mM HEPES, 150 mM NaCl, pH 7.2, 10 mM TCEP
• Endotoxin: Less than 0.1 EU/µg (<0.01 ng/µg) protein as determined by the LAL method
• Storage: Store at -80°C.
• Stability: Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.

Reference Data

• RefSeq: NP_598536
• Locus ID: 77125
• UniProt ID: Q8BVZ5
• Cytogenetics: 19 C1
• Refseq Size: 2534
• Refseq ORF: 798
• Synonyms: 9230117N10Rik; Il-33; Il1f11; NF-HEV
• Summary: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury.[UniProtKB/Swiss-Prot Function]