Il17a (NM_010552) Mouse Recombinant Protein
Purified recombinant protein of Mouse interleukin 17A (Il17a)
Product Datasheet for 'TP723750'
|Description||Purified recombinant protein of Mouse interleukin 17A (Il17a)|
|Expression Host||E. coli|
|Expression cDNA Clone or AA Sequence||Mouse IL-17A, the region of Ala26-Ala158, from gene Accession# NM_010552|
|Predicted MW||15 kDa|
|Concentration||Protein formulated and vialed at >50 ug/mL in specified buffer|
|Purity||Purity is >98%, as determined by Coomassie stained SDS-PAGE.|
|Buffer||10 mM NaH2PO4, 0.15 M NaCl, pH7.2|
|Bioactivity||The ED50 is 0.25 - 1 ng/ml, corresponding to a specific activity 1.0 - 4 x 10^6 units/mg, determined by a dose dependent stimulation of fetal mouse skin fibroblasts production of IL-6.|
|Endotoxin||Less than 0.01 ng per ug protein as determined by the LAL method.|
|Synonyms||Ctla-8; Ctla8; IL-17; IL-17A; Il17|
|Summary||This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]|
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