Il21 (NM_021782) Mouse Recombinant Protein

CAT#: TP723736

Purified recombinant protein of Mouse interleukin 21 (Il21)

Specifications

Product Data

• Species: Mouse
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Mouse Il21, the region of Pro25-Ser146, from gene accession# NM_021782.3
• Tag: Tag Free
• Predicted MW: 14.2 kDa
• Concentration: lot specific
• Purity: >98%, as determined by Coomassie stained SDS-PAGE.
• Buffer: 1 x PBS
• Bioactivity: The ED50 is 15 - 60 ng/ml, corresponding to a specific activity of 1.7 - 6.7 x 10^4 units/mg.
• Endotoxin: Less than 0.01 ng per µg protein as determined by the LAL method
• Storage: Store at -80°C.
• Stability: Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.

Reference Data

• RefSeq: NP_068554
• Locus ID: 60505
• UniProt ID: Q9ES17, Q5SUE2
• Cytogenetics: 3 B
• Refseq Size: 3090
• Refseq ORF: 438
• Synonyms: IL-21
• Summary: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.[UniProtKB/Swiss-Prot Function]