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Il4 (NM_021283) Mouse Recombinant Protein

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SKU
TP723734
Purified recombinant protein of Mouse interleukin 4 (Il4), transcript variant 1
Size:
10 ug
  $345.00
5 Days*
Bulk/Customize

Frequently Bought Together (1)

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200 ug
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Specifications
Specifications
Product Data
Species Mouse
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
Mouse IL-4, the region of His23-Ser140, from gene Accession# NM_021283
Tag Tag Free
Predicted MW 13.3 kDa
Concentration lot specific
Purity >95%, as determined by Coomassie stained SDS-PAGE.
Buffer 1 x PBS
Bioactivity The ED50 is 2 - 4 ng/ml, corresponding to a specific activity of 2.5 - 5 x 10^5 units/mg, determined by CTLL-2 cell proliferation induced by mouse IL-4 in a dose dependent manner.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method
Storage Store at -80°C.
Stability Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_067258
Locus ID 16189
UniProt ID P07750
Cytogenetics 11 31.97 cM
RefSeq Size 605
RefSeq ORF 420
Synonyms BSF-1; Il-4
Summary Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3083412). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301). It enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301). It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (PubMed:25847241). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (PubMed:26416964).UniProtKB/Swiss-Prot Function
Protein Categories Allergies and autoimmune diseases, Cytokines, Growth Factors, Secreated Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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