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CD19 Human Recombinant Protein

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SKU
TP721368
APC Conjugated Human CD19 Protein (C-Fc)
Size:
25 ug 100 ug
  $430.00
5 Days*
Bulk/Customize

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Specifications
Specifications
Product Data
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence
Protein Sequence
Glu21-Lys291
Tag C-Fc
Predicted MW The protein has a predicted molecular weight of 56kDa and migrates at approximately 70-80kDa on SDS-PAGE with DTT-reduced condition before APC conjugation.
Concentration 25µg size is bottled at 0.1mg/mL concentration. 100 µg size is bottled at lot specific concentration.
Purity >90%
Conjugation APC
Presentation State Purified
Buffer 1xPBS buffer, pH7.4, 0.09% NaN3 with a carrier protein
Bioactivity Positive

The definition of the active protein (purified and biotinylated) is defined as the protein that can bind to its biological receptor/ligand. For conjugated protein, it is defined with its function to bind to the ScFv of the active CAR-transfected cells in flow cytometry test.
Preparation Affinity Protein A
Recommended Dilution FACS
Storage An unopened vial can be stored at 4°C for 2 weeks or at -20°C and below for six months. This stock solution should be aliquoted and stored at ≤ -70°C to minimize the freeze/thaw cycles.
Stability 6 Months
Shipping Blue Ice
Reference Data
RefSeq P15391
Locus ID 930
UniProt ID P15391
Summary CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. CD19 Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen.
Protein Families FACS
Protein Pathways B cell receptor signaling pathway, Hematopoietic cell lineage, Primary immunodeficiency
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Other "CD19" proteins (11)
SKU Description Size Price
PH302922 CD19 MS Standard C13 and N15-labeled recombinant protein (NP_001761) 10 ug
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LC400678 Lyophilized CD19 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
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LY400678 Transient overexpression lysate of CD19 molecule (CD19) (as WB positive control) 100 ug
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TP302922 Recombinant protein of human CD19 molecule (CD19), 20 µg 20 ug
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TP700276 Purified recombinant protein of human CD19 molecule (CD19), transcript variant 2, with C-terminal Fc tag, expressed in human cells, 20 µg 20 ug
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TP700295 Purified recombinant protein of human CD19 molecule (CD19), transcript variant 2, with C-terminal DDK/His tag, expressed in human cells, 20 µg 20 ug
$900.00
TP721364 Human CD19 Protein (C-Fc) 25 ug
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TP721365 Human CD19 Protein (C-Fc-Avi) 25 ug
$300.00
TP721366 Biotinylated Human CD19 Protein (C-Fc-Avi) 25 ug
$430.00
TP721367 PE Conjugated Human CD19 Protein (C-Fc) 25 ug
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TP762435 Purified recombinant protein of Human CD19 molecule (CD19), transcript variant 2, Gln314-End, with N-terminal His tag, expressed in E.coli, 50ug 50 ug
$240.00

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