IFNA13 (IFNA1) (NM_024013) Human Recombinant Protein

SKU
TP721103
Purified recombinant protein of Human interferon, alpha 1 (IFNA1)
  $340.00
7 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
Cys24-Glu189
Tag C-His
Predicted MW 20.4 kDa
Concentration lot specific
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Endotoxin Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Reconstitution Method Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilized protein in ddH2O. It is not recommended to reconstitute a concentration less than 100 µg/ml. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Shipping Ambient
Reference Data
RefSeq NP_076918
Locus ID 3439
UniProt ID P01562
Cytogenetics 9p21.3
RefSeq Size 863
RefSeq ORF 567
Synonyms IFL; IFN; IFN-ALPHA; IFN-alphaD; IFNA13; IFNA@; leIF D
Summary This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. This cytokine is upregulated in preeclamptic placentas and is thought to be a mediator of preeclampsia. provided by RefSeq, Aug 2020
Protein Categories Cytokines, Secreated Proteins
Protein Families Druggable Genome
Protein Pathways Antigen processing and presentation, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Regulation of autophagy, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway
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Other "IFNA13" proteins (4)
SKU Description Size Price
PH310902 IFNA1 MS Standard C13 and N15-labeled recombinant protein (NP_076918) 10 ug
$3,360.00
LC402974 Lyophilized IFNA1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY402974 Transient overexpression lysate of interferon, alpha 1 (IFNA1) (as WB positive control) 100 ug
$436.00
TP310902 Recombinant protein of human interferon, alpha 1 (IFNA1), 20 µg 20 ug
$867.00

file-alt Citations

X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia
Abolhassani, Vosughimotlagh, Asano et al
J Clin Immunol (2021)
Cited by 48
AI Summary: OriGene’s Myc-DDK-pCMV6 vector was used to re-introduce wild-type or variant TLR7 alleles into HEK293T cells, enabling functional analysis of the TLR7 mutation identified in the patient.
Snippet: The WT or variant allele (L372M) was re-introduced into a Myc-DDK-pCMV6 vector (Origene). HEK293T cells, which have no endogenous TLR7 expression, were transfected with the Myc-DDK-pCMV6 vector, empty or containing the WT or a variant allele (L372M), Save;- The WT or variant allele (L372M) was re-introduced into a Myc-DDK-pCMV6 vector (Origene). HEK293T cells, which have no endogenous TLR7 e...
FigureFigure
Showing 1-1 of 1 papers.
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