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STAT6 (NM_003153) Human Recombinant Protein

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SKU
TP720974
Purified recombinant protein of Human signal transducer and activator of transcription 6, interleukin-4 induced (STAT6), transcript variant 2
Size:
10 ug 500 ug 50 ug 1 mg
  $340.00
7 Weeks*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
Ser627-Ser837
Tag C-His
Predicted MW 23.9 kDa
Concentration lot specific
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Endotoxin Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Reconstitution Method Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilized protein in ddH2O. It is not recommended to reconstitute a concentration less than 100 µg/ml. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Shipping Ambient
Reference Data
RefSeq NP_003144
Locus ID 6778
UniProt ID P42226
Cytogenetics 12q13.3
RefSeq Size 4031
RefSeq ORF 2541
Synonyms D12S1644; IL-4-STAT; STAT6B; STAT6C
Summary The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.provided by RefSeq, May 2010
Protein Categories Cytokines, Growth Factors, Intracellular Proteins, Transciption Factors
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors
Protein Pathways Jak-STAT signaling pathway
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Other "STAT6" proteins (4)
SKU Description Size Price
PH310065 STAT6 MS Standard C13 and N15-labeled recombinant protein (NP_003144) 10 ug
$3,360.00
LC401100 Lyophilized STAT6 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY401100 Transient overexpression lysate of signal transducer and activator of transcription 6, interleukin-4 induced (STAT6) (as WB positive control) 100 ug
$436.00
TP310065 Recombinant protein of human signal transducer and activator of transcription 6, interleukin-4 induced (STAT6), 20 µg 20 ug
$867.00

file-alt Citations

PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
Iwata, Goettsch, Sharma et al
Nat Commun (2016) 7, 12849 DOI: 10.1038/ncomms12849
Cited by 310
AI Summary: In this study, the recombinant human STAT1α protein from OriGene Technologies was used in ADP-ribosylation assays to investigate how PARP9 and PARP14 regulate macrophage activation through STAT1 modification.
Snippet: … ADP-ribosylation assays Recombinant human PARP14 and PARP9 (BPS Bioscience Inc.) proteins and BSA (Sigma-Aldrich) were incubated with recombinant human STAT1α (OriGene Technologies Inc.) or STAT6 protein (Sino Biological Inc.) at a final concentration of 5 ng μl−1 in the presence of 100 μM β-nicotinamide adenine dinucleotide hydrate (NAD;Sigma-Al;Recombinant human PARP14 and PARP9 (BPS Bioscience Inc.) proteins and BSA (Sigma-Aldrich) were incubated with recombinant human STAT1α (OriGene Technologies Inc.) or STAT6 protein (Sino Biological Inc.) at a final concentration of 5 ng μl−1 in the presence of 100 μM β-nicotinamide adenine dinucleotide hydrate (NAD;Sigma-Aldrich) or 6-biotin-17-NAD (Trevigen Inc.) in 50 mM Tris-HCl buffer (pH 7.4) for 1 h at room temperature
FigureFigureFigure
Showing 1-1 of 1 papers.
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