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Complement factor B (CFB) (NM_001710) Human Recombinant Protein

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SKU
TP720638
Purified recombinant protein of Human complement factor B (CFB)
Size:
10 ug 500 ug 50 ug 1 mg
  $275.00
5 Days*
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
Thr26-Leu764
Tag C-His
Predicted MW 84.07 kDa
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Endotoxin Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Storage Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Stability Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_001701
Locus ID 629
UniProt ID P00751
Cytogenetics 6p21.33
RefSeq Size 2646
RefSeq ORF 2292
Synonyms AHUS4; ARMD14; BF; BFD; CFAB; CFBD; FB; FBI12; GBG; H2-Bf; PBF2
Summary This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. provided by RefSeq, Jul 2008
Protein Categories Cardiovascular diseases, Enzyme: Peptidases, Immune system diseases, Nervous system Diseases, Secreated Proteins
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Complement and coagulation cascades
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Other "Complement factor B" proteins (4)
SKU Description Size Price
PH300499 CFB MS Standard C13 and N15-labeled recombinant protein (NP_001701) 10 ug
$3,360.00
LC400641 Lyophilized CFB HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400641 Transient overexpression lysate of complement factor B (CFB) (as WB positive control) 100 ug
$436.00
TP300499 Recombinant protein of human complement factor B (CFB), 20 µg 20 ug
$737.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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