SLAMF7 (NM_021181) Human Recombinant Protein
CAT#: TP720631
Purified recombinant protein of Human SLAM family member 7 (SLAMF7)
Product Images
Specifications
Product Data | |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence |
Ser23-Met226
|
Tag | C-His |
Predicted MW | 23.3 kDa |
Concentration | N/A |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Provided lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4 |
Endotoxin | Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
Reconstitution | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilized protein in ddH2O. It is not recommended to reconstitute a concentration less than 100 µg/ml. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Storage | Store at -80°C. |
Stability | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
Reference Data | |
RefSeq | NP_067004 |
Locus ID | 57823 |
UniProt ID | Q9NQ25 |
Cytogenetics | 1q23.3 |
Refseq Size | 2672 |
Refseq ORF | 1005 |
Synonyms | 19A; CD319; CRACC; CS1 |
Summary | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).[UniProtKB/Swiss-Prot Function] |
Protein Families | Druggable Genome, Transmembrane |
Documents
FAQs |
SDS |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC402852 | SLAMF7 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 134.00 |
|
LY402852 | Transient overexpression lysate of SLAM family member 7 (SLAMF7) |
USD 436.00 |
|
PH320985 | SLAMF7 MS Standard C13 and N15-labeled recombinant protein (NP_067004) |
USD 3,255.00 |
|
TP320985 | Recombinant protein of human SLAM family member 7 (SLAMF7), 20 µg |
USD 867.00 |
|
TP723925 | Human CS1 Protein, hFc-His Tag |
USD 575.00 |
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