CTRB1 (NM_001906) Human Recombinant Protein

CAT#: TP720408

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Recombinant Human Chymotrypsingen B/CTRB

  View other "CTRB1" proteins (4)

USD 330.00

3 Weeks

    • 10 ug

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Product Data
Description Recombinant Human Chymotrypsingen B/CTRB
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC202806, encoding the secreted form (Cys19-Asn263) of human CTRB1
Predicted MW 26.9 kDa
Concentration lot specific
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Endotoxin < 0.1 EU per µg protein as determined by LAL test
Storage Store at -80°C.
Stability Stable for at least 3 months from date of receipt under proper storage and handling conditions.
Reference Data
RefSeq NP_001897
Locus ID 1504
UniProt ID P17538
Cytogenetics 16q23.1
Refseq Size 873
Refseq ORF 789
Synonyms CTRB
Summary This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This CTRB1 gene is located head-to-head with the related CTRB2 gene. Some human populations have an alternate haplotype which inverts a 16.6 Kb region containing portions of intron 1, exon 1, and the upstream sequence of the CTRB1 and CTRB2 genes. In this inversion haplotype exon 1 and flanking sequence is swapped in CTRB1 and CTRB2. This inversion is associated with differential gene expression and increased risk for chronic pancreatitis. The GRCh38 assembly represents the minor allele for SNP rs8048956 of the CTRB1 gene. SNP rs8048956 in intron 1 of the CTRB2 gene is diagnostic for this inversion. This CTRB1 gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Jan 2021]
Protein Families Druggable Genome, Protease, Secreted Protein, Transmembrane


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