B7-2 (CD86) (NM_006889) Human Recombinant Protein

CAT#: TP720346

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Recombinant protein of human CD86 molecule (CD86), transcript variant 2



  View other "CD86" proteins (1)

USD 300.00


Availability*
2 Weeks

Size
    • 10 ug


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Specifications

Product Data
Description Recombinant protein of human CD86 molecule (CD86), transcript variant 2
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC206513, encoding the polypeptide (Ala24-Pro247) of human CD86
Tag C-His
Predicted MW 26.7 kDa
Concentration Resuspend the protein to the desired concentration in proper buffer.
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.2.
Endotoxin < 0.1 EU per µg protein as determined by LAL test
Storage Store at -80°C.
Stability Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Reference Data
RefSeq NP_008820
Locus ID 942
Refseq Size 2794
Cytogenetics 3q13.33
Refseq ORF 969
Synonyms B7-2; B7.2; B70; CD28LG2; LAB72
Summary This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, May 2011]
Protein Families Druggable Genome, Transcription Factors, Transmembrane
Protein Pathways Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Graft-versus-host disease, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Viral myocarditis

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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