MDH1 (NM_001199111) Human Recombinant Protein

CAT#: TP720248

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Recombinant protein of human malate dehydrogenase 1, NAD (soluble) (MDH1), transcript variant 1.


 Product Datasheet for 'TP720248'

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USD 299.00


Availability*
2 Weeks

Size
    • 10 ug


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Specifications

Product Data
Description Recombinant protein of human malate dehydrogenase 1, NAD (soluble) (MDH1), transcript variant 1.
Species Human
Expression Host E. coli
Tag C-His
Predicted MW 37.5 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer 20mM Tris, 150mM NaCl, pH 8.0.
Endotoxin < 0.1 EU per µg protein as determined by LAL test
Reference Data
RefSeq NP_001186040
Locus ID 4190
Cytogenetics 2p15
Refseq ORF 1056
Synonyms HEL-S-32; MDH-s; MDHA; MGC:1375; MOR2
Summary This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq, Feb 2016]
Protein Families Druggable Genome
Protein Pathways Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, Metabolic pathways, Pyruvate metabolism

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