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PPM1A (NM_021003) Human Recombinant Protein

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SKU
TP720139
Recombinant protein of human protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform (PPM1A), transcript variant 1
Size:
10 ug 500 ug 50 ug 1 mg
  $235.00
7 Weeks*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
Gly2-Trp382
Tag C-His
Predicted MW 43.5 kDa
Concentration lot specific
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Endotoxin < 0.1 EU per µg protein as determined by LAL test
Storage Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Stability Stable for at least 3 months from date of receipt under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_066283
Locus ID 5494
UniProt ID P35813
Cytogenetics 14q23.1
Synonyms PP2C-ALPHA; PP2CA; PP2Calpha
Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. provided by RefSeq, Jul 2008
Protein Categories Growth Factors, Intracellular Proteins
Protein Families Druggable Genome, Phosphatase
Protein Pathways MAPK signaling pathway
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Other "PPM1A" proteins (7)
SKU Description Size Price
PH302070 PPM1A MS Standard C13 and N15-labeled recombinant protein (NP_066283) 10 ug
$3,360.00
LC402820 Lyophilized PPM1A HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC406056 Lyophilized PPM1A HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY402820 Transient overexpression lysate of protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform (PPM1A), transcript variant 1 (as WB positive control) 100 ug
$436.00
LY406056 Transient overexpression lysate of protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform (PPM1A), transcript variant 2 (as WB positive control) 100 ug
$436.00
TP302070 Recombinant protein of human protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform (PPM1A), transcript variant 1, 20 µg 20 ug
$867.00
TP329231 Recombinant protein of human protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform (PPM1A), transcript variant 3, 20 µg 20 ug
$867.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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