OGG1 (NM_002542) Human Recombinant Protein
SKU
TP720109
Recombinant protein of human 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 1a
$275.00
7 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | |
| Tag | N-GST |
| Predicted MW | 65.1 kDa |
| Concentration | lot specific |
| Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | Supplied as a 0.2 um filtered solution of 20mMTris-HCl,150mMNacl,1mMEDTA,pH8.5. |
| Endotoxin | < 0.1 EU per µg protein as determined by LAL test |
| Storage | Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
| Stability | Stable for at least 3 months from date of receipt under proper storage and handling conditions. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_002533 |
| Locus ID | 4968 |
| UniProt ID | O15527 |
| Cytogenetics | 3p25.3 |
| Synonyms | HMMH; HOGG1; MUTM; OGH1 |
| Summary | This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. provided by RefSeq, Aug 2008 |
| Protein Categories | Cancer: Bladder, Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Base excision repair |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "OGG1" proteins (11)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| LC413811 | Lyophilized OGG1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
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| LC413813 | Lyophilized OGG1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC413815 | Lyophilized OGG1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC413816 | Lyophilized OGG1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC413835 | Lyophilized OGG1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY413811 | Transient overexpression lysate of 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 2a (as WB positive control) | 100 ug |
$665.00
|
|
| LY413813 | Transient overexpression lysate of 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 2b (as WB positive control) | 100 ug |
$436.00
|
|
| LY413815 | Transient overexpression lysate of 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 2d (as WB positive control) | 100 ug |
$436.00
|
|
| LY413816 | Transient overexpression lysate of 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 2e (as WB positive control) | 100 ug |
$436.00
|
|
| LY413835 | Transient overexpression lysate of 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 1b (as WB positive control) | 100 ug |
$436.00
|
|
| TP760967 | Purified recombinant protein of Human 8-oxoguanine DNA glycosylase (OGG1), nuclear gene encoding mitochondrial protein, transcript variant 2a, full length, with N-terminal HIS tag, expressed in E. coli, 50ug | 50 ug |
$270.00
|
|
Citations
8-Oxoguanine DNA Glycosylase1 conceals oxidized guanine in nucleoprotein-associated RNA of respiratory syncytial virus
Pan, Wang, Hao et al
PLoS Pathog (2024) 20 (10), e1012616 DOI: 10.1371/journal.ppat.1012616
Pan, Wang, Hao et al
PLoS Pathog (2024) 20 (10), e1012616 DOI: 10.1371/journal.ppat.1012616
Cited by 5
AI Summary: OriGene’s GST-tagged OGG1 protein (TP720109) was used in this study to investigate the interaction between OGG1 and RSV nucleoproteins, enabling the authors to elucidate how RSV exploits host OGG1 to manage oxidized guanine in its RNA.
Snippet: Glutathione Agarose (16100, Thermo Scientific) and Dynabeads (10103D, Invitrogen) were utilized following the recommendations provided by their manufacturers. Specifically, GST-tagged OGG1 (TP720109, OriGene, Rockville, MD) was immobilized onto Glutathione Agarose, and subsequently incubated with varying concentrations of His-tagged nucleoprotein (NP-424V, Creative BioMart, Shirley, NY), or His-ta
Reactive oxygen species induced by icaritin promote DNA strand breaks and apoptosis in human cervical cancer cells
Chen, Song, Hou et al
Oncol. Rep. (2018)
Chen, Song, Hou et al
Oncol. Rep. (2018)
AI Summary: OriGene's 8-oxoguanine glycosylase (OGG1) was used in this study to detect oxidative DNA damage in cervical cancer cells treated with icaritin, helping to demonstrate the compound's ability to induce DNA strand breaks through increased reactive oxygen species.
Snippet: The slides were washed twice in enzyme buffer (40 mM HEPES, 0.1 M KCl, 0.5 mM EDTA and 0.2 mg/ml BSA, pH 8.0) and then incubated in enzyme buffer with or without 8-oxoguanine glycosylase (OGG1;1.0 µg/ml;OriGene Technologies, Inc., Rockville, MD, USA
Showing 1-2 of 2 papers.
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