c Kit (KIT) (NM_000222) Human Recombinant Protein

CAT#: TP710114

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Recombinant protein of human v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), transcript variant 1, residues 546-976aa, with C-terminal DDK tag,expressed in sf9 cells


Product Datasheet for 'TP710114'


  View other "KIT" proteins (6)

USD 425.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), transcript variant 1, residues 546-976aa, with C-terminal DDK tag,expressed in sf9 cells
Species Human
Expression Host Sf9
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC209839, encoding the region(Met-Lys546-Val976) of Homo sapiens KIT
Tag C-DDK
Predicted MW 48.7 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_000213
Locus ID 3815
Refseq Size 5084
Cytogenetics 4q12
Refseq ORF 2928
Synonyms C-Kit; CD117; MASTC; PBT; SCFR
Summary This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]
Protein Families Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Protein Kinase, Stem cell - Pluripotency, Transmembrane
Protein Pathways Acute myeloid leukemia, Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer

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Other Versions

Frequently bought together (1)
KIT (c-Kit ) mouse monoclonal antibody, clone OTI9A11 (formerly 9A11)
    • 100 ul

USD 379.00

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