ErbB 3 (ERBB3) (NM_001982) Human Recombinant Protein

CAT#: TP710091

Recombinant protein of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant 1, residues 20-643, with C-terminal DDK tag, expressed in sf9, 20ug


 Product Datasheet for 'TP710091'

  View other "ERBB3" proteins (16)

USD 411.00


Availability*
In Stock

Size
    • 20 ug


Product images

Specifications

Product Data
Description Recombinant protein of human v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3), transcript variant 1, residues 20-643, with C-terminal DDK tag, expressed in sf9, 20ug
Species Human
Expression Host Sf9
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC209954, encoding the region(Met-Ser20-Thr643) of Homo sapiens ERBB3
Tag C-DDK
Predicted MW 68.7 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol
Reference Data
RefSeq NP_001973
Locus ID 2065
Refseq Size 5511
Cytogenetics 12q13.2
Refseq ORF 4026
Synonyms c-erbB-3; c-erbB3; ErbB-3; erbB3-S; HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3
Summary This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Protein Families Adult stem cells, Druggable Genome, Protein Kinase, Secreted Protein, Stem cell - Pluripotency, Transmembrane
Protein Pathways Calcium signaling pathway, Endocytosis, ErbB signaling pathway

Documents

Other Versions

Other products for "ERBB3"
Frequently bought together (1)
ERBB3 mouse monoclonal antibody, clone OTI3E10 (formerly 3E10)
    • 100 ul

USD 360.00

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
40% off proteins and antibodies
68 Mouse Clones