ALK (NM_004304) Human Recombinant Protein

CAT#: TP710037

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Recombinant protein of human anaplastic lymphoma receptor tyrosine kinase (ALK),residues residues 1060-1620, with N-terminal polyhistidine tag, expressed in sf9 cells.



  View other "ALK" proteins (5)

USD 425.00


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    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human anaplastic lymphoma receptor tyrosine kinase (ALK),residues residues 1060-1620, with N-terminal polyhistidine tag, expressed in sf9 cells.
Species Human
Expression Host Sf9
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC222485, encoding the region (Arg1060-Pro1620) of human ALK
Tag N-His
Predicted MW 62 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris-HCl pH8.0, 150mM NaCl, 10%glycerol
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_004295
Locus ID 238
Refseq Size 6222
Cytogenetics 2p23.2-p23.1
Refseq ORF 4860
Synonyms CD246; NBLST3
Summary This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X). [provided by RefSeq, Jan 2011]
Protein Families Druggable Genome, Protein Kinase

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Frequently bought together (1)
ALK mouse monoclonal antibody, clone OTI1A4 (discontinued and upgraded to UltraMAB UM800118)
    • 100 ul

USD 379.00

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