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ATF2 (NM_001880) Human Recombinant Protein

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SKU
TP710017
Recombinant protein of human activating transcription factor 2 (ATF2), full length, with C-terminal polyhistidine tag, expressed in sf9 cells.
Size:
20 ug
  $540.00
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Specifications
Specifications
Product Data
Species Human
Expression Host Sf9
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence from TrueORF clone, RC218983, encoding human full-length ATF2
Tag C-His
Predicted MW 55 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50 mM Tris-HCl, pH 8.0, 150 mM NaCl, 20% glycerol
Bioactivity In vitro kinase assay substrate (PMID: 28298524)
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_001871
Locus ID 1386
UniProt ID P15336
Cytogenetics 2q31.1
RefSeq Size 2117
RefSeq ORF 1515
Synonyms CRE-BP1; CREB-2; CREB2; HB16; TREB7
Summary This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene provided by RefSeq, Jan 2014
Protein Categories Growth Factors, Intracellular Proteins, Transciption Factors
Protein Families Druggable Genome, Transcription Factors
Protein Pathways MAPK signaling pathway
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Documents
Resources
Other "ATF2" proteins (1)
SKU Description Size Price
TP760496 Purified recombinant protein of Human activating transcription factor 2 (ATF2), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug 50 ug
$270.00

file-alt Citations

Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity
Shah, Tulapurkar, Ramarathnam et al
J. Immunol. (2017)
AI Summary: OriGene contributed to this study by providing the activating transcription factor (ATF) 2 protein (product: TP710017), which was used in the biochemical assays to investigate the effects of novel p38α-specific MAPK inhibitors.
Snippet: Recombinant MK2, STAT-1a, and acti- vating transcription factor (ATF) 2 protein were purchased from Thermo Fisher Scientific (PV3317), SignalChem (Richmond, BC, Canada) (S52- 50G), and Origene (Rockville, MD) (TP710017), respectively. ... All 2 versions Cite SaveSaving
Showing 1-1 of 1 papers.
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