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Thymidine Kinase 1 (TK1) (NM_003258) Human Recombinant Protein

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SKU
TP700037
Recombinant protein of human thymidine kinase 1, soluble (TK1), expressed in human cells
Size:
20 ug
  $900.00
In Stock*
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Frequently Bought Together (1)

TA314626 Rabbit polyclonal TK (Ab-13) antibody
100 ul
$380.00

Other products for "Thymidine Kinase 1 or NM_003258"

Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence from TrueORF clone, RC218280, encoding human full-length TK1
Tag C-DDK
Predicted MW 27 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_003249
Locus ID 7083
UniProt ID P04183
Cytogenetics 17q25.3
RefSeq Size 1616
RefSeq ORF 702
Synonyms TK2
Summary The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. provided by RefSeq, Oct 2016
Protein Categories Intracellular Proteins
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways Drug metabolism - other enzymes, Metabolic pathways, Pyrimidine metabolism
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Other "Thymidine Kinase 1" proteins (2)
SKU Description Size Price
LC418805 Lyophilized TK1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY418805 Transient overexpression lysate of thymidine kinase 1, soluble (TK1) (as WB positive control) 100 ug
$436.00

file-alt Citations

Cellular influx, efflux, and anabolism of 3-carboranyl thymidine analogs: potential boron delivery agents for neutron capture therapy
Sjuvarsson, Damaraju, Mowles et al
J Pharmacol Exp Ther (2013) 347 (2), 388-97 DOI: 10.1124/jpet.113.207464
Cited by 17
AI Summary: OriGene products contributed to this study by providing the human CCRF-CEM cell line (Cat# CRL-2265) and murine L929 cell line (Cat# NCL-1), which were used to investigate the cellular uptake and metabolism of 3-carboranyl thymidine analogs.
Showing 1-1 of 1 papers.
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