Tgfb1 (NM_011577) Mouse Recombinant Protein
SKU
TP527339
Purified recombinant protein of Mouse transforming growth factor, beta 1 (Tgfb1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
$1,020.00
In Stock*
Specifications
| Product Data | |
| Species | Mouse |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-MYC/DDK |
| Predicted MW | 44.8 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C after receiving vials. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_035707 |
| Locus ID | 21803 |
| UniProt ID | P04202 |
| Cytogenetics | 7 13.98 cM |
| RefSeq Size | 2094 |
| RefSeq ORF | 1170 |
| Synonyms | TGF-beta; TGF-beta1; Tgfb; Tgfb-1; TGFbeta; TGFbeta1 |
| Summary | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. Mice lacking a functional copy of this gene develop severe multifocal inflammatory disease, yolk sac defects and colon cancer. provided by RefSeq, Aug 2016 |
| Protein Categories | Allergies and autoimmune diseases, Growth Factors, Secreated Proteins |
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Resources
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Citations
TGF-β1 mediates the radiation response of prostate cancer
Wu, Hsieh, Yen et al
J. Mol. Med. (2014)
Wu, Hsieh, Yen et al
J. Mol. Med. (2014)
Cited by 35
AI Summary: OriGene Technologies contributed TGF-β1 shRNA constructs and control shRNA vectors, which were used in this study to experimentally silence TGF-β1 and investigate its role in the radiation response of prostate cancer cells.
Snippet: human prostate cancer cells, as described previously [2]. In addition, TGF-β1- silencing vectors (the TGF-β1 shRNA construct in retroviral vector with puromycin resistance) or control vectors (the scrambled shRNA in vector) were purchased from OriGene Technologies ... Cite SaveSaving
Showing 1-1 of 1 papers.
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