Stat3 (NM_213659) Mouse Recombinant Protein
SKU
TP527265
Purified recombinant protein of Mouse signal transducer and activator of transcription 3 (Stat3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
$1,020.00
4 Weeks*
Specifications
| Product Data | |
| Species | Mouse |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-MYC/DDK |
| Predicted MW | 88.5 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C after receiving vials. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_998824 |
| Locus ID | 20848 |
| UniProt ID | P42227 |
| Cytogenetics | 11 63.82 cM |
| RefSeq Size | 4487 |
| RefSeq ORF | 2310 |
| Synonyms | 1110034C02Rik; A; Aprf; AW109958 |
| Summary | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Alternative splicing results in multiple transcript variants encoding distinct isoforms. provided by RefSeq, Sep 2015 |
| Protein Categories | Allergies and autoimmune diseases, Cancer: Head and Neck, Cytokines, Growth Factors, Intracellular Proteins, Transciption Factors |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production
Nishanth, Deckert, Wex et al
PLoS Pathog. (2013) 9 (6), e1003455 DOI: 10.1371/journal.ppat.1003455
Nishanth, Deckert, Wex et al
PLoS Pathog. (2013) 9 (6), e1003455 DOI: 10.1371/journal.ppat.1003455
Cited by 38
AI Summary: OriGene products contributed to this study by providing the mouse STAT3 (SR421378) and mouse IL-6 (SR420845) siRNAs used for in vivo gene silencing experiments, enabling the authors to investigate the roles of STAT3 and IL-6 in CYLD-mediated regulation of fibrin production during listeriosis.
Snippet: Listeria monocytogenes (Lm) is a facultative intracellular, gram-positive rod, which may cause life threatening infections in the elderly (>65 years), immunocompromised patients and fetuses [1]. Clinically, listeriosis can present as septicaemia, disseminated inflammatory
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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