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Pcbp2 (NM_001103165) Mouse Recombinant Protein

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SKU
TP522190
Purified recombinant protein of Mouse poly(rC) binding protein 2 (Pcbp2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Size:
20 ug
  $1,020.00
4 Weeks*
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Specifications
Specifications
Product Data
Species Mouse
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence from Mouse cDNA ORF Clone, MR222190, encoding Mouse full-length Pcbp2.
Tag C-MYC/DDK
Predicted MW 38.7 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C after receiving vials.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_001096635
Locus ID 18521
UniProt ID Q61990
Cytogenetics 15 57.61 cM
RefSeq Size 2868
RefSeq ORF 1086
Synonyms alphaCP-2; AW412548; Hnrpx
Summary Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation (By similarity).UniProtKB/Swiss-Prot Function
Protein Categories Intracellular Proteins
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Documents
Resources

file-alt Citations

Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading
Marocco, Garbo, Montaldo et al
Elife (2025) 14 DOI: 10.7554/eLife.105017
AI Summary: OriGene's mouse recombinant PCBP2 protein (TP522190) was used in pull-down assays to investigate PCBP2's direct binding to miRNAs, thereby elucidating its role in regulating miRNA sorting into extracellular vesicles.
Snippet: S). Detection of miRNA/RBPs interaction was evaluated by WB on 10% of Input sample and 50% of the pulled-down samples. Pull-down assay with PCBP2 (NM_001103165) mouse recombinant protein (TP522190, Origene) was performed with 4 μg of protein. Protein digestion, peptide purification, and nanoLC analysis Proteins obtained from the pull-down experiments with miR-155-3p or random scrambled miRNA we
FigureFigureFigure
Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading
Marocco, Garbo, Montaldo et al
bioRxiv (2024)
Snippet: Detection of miRNA/RBPs interaction was evaluated by WB on 10% of Input sample and 50% of the pulled-down samples. Pull down assay with the recombinant PCBP2 (PCBP2 (NM_001103165) mouse recombinant protein TP522190, Origene) was performed with 4ug of protein
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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