OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

Map3k1 (NM_011945) Mouse Recombinant Protein

Be the first to review this product
SKU
TP522089
Purified recombinant protein of Mouse mitogen-activated protein kinase kinase kinase 1 (Map3k1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Size:
20 ug
  $1,020.00
4 Weeks*
Bulk/Customize

Frequently Bought Together (1)

TA592569 DDK Rabbit monoclonal antibody, recognizing both N- and C-terminal tags
100 ul
$519.00

Other products for "Map3k1 or NM_011945"

Specifications
Specifications
Product Data
Species Mouse
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
>MR222089 representing NM_011945
Red=Cloning site Green=Tags(s)

MAAAAGDRASSSGFPGAAAASPEAGGGGGGGGALQGSGAPAAGAAGLLREPGSAGRERADWRRRQLRKVR
SVELDQLPEQPLFLAAASPPCPSTSPSPEPADAAAGASRFQPAAGPPPPGAASRCGSHSAELAAARDSGA
RSPAGAEPPSAAAPSGREMENKETLKGLHKMEDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKP
IPIKGDGSEMNNLAAEPQGEGQAGSAAPAPKGRRSPSPGSSPSGRSVKPESPGVRRKRVSPVPFQSGRIT
PPRRAPSPDGFSPYSPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCGRGAFC
IHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNCHTLSSSS
TSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKW
RSHDFYSHELSSPVESPTSLRAVQQPSSPQQPVAGSQRRNQESSFNLTHFGTQQIPSAYKDLAEPWIQVF
GMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGGSGGSLSAGAASGSSQPSISGDVVEA
CCSVLSIVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDTILVKCADANSRTSQLSIS
TVLELCKGQAGELAVGREILKAGSIGVGGVDYVLSCILGNQAESNNWQELLGRLCLIDRLLLEFPAEFYP
HIVSTDVSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTAVPAVFSKLVTMLNAS
GSTHFTRMRRRLMAIADEVEIAEVIQLGVEDTVDGHQDSLQVLAPASCLENSSLEHTVHREKTGKGLSAT
RLSASSEDISDRLAGVSVGLPSSTTTEQPKPAVQTKGRPHSQCLNSSPLSHAQLMFPAPSAPCSSAPSVP
DISKHRPQAFVPCKIPSASPQTQRKFSLQFQRNCSEHRDSDQLSPVFTQSRPPPSSNIHRPKPSRPVPGS
TSKLGDATKSSMTLDLGSASRCDDSFGGGGNSGNAVIPSEETVFTPVEDKCRLDVNTELNSSIEDLLEAS
MPSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQ
VENGEDIIIIQQDTPETLPGHTKAKQPYREDAEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRN
TSSEQEEVVEALREEIRMMGHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINY
TEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPE
VLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCL
ELQPQDRPPSRELLKHPVFRTTW

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag C-MYC/DDK
Predicted MW 161.4 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C after receiving vials.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_036075
Locus ID 26401
UniProt ID F8VQ72
Cytogenetics 13 63.36 cM
RefSeq Size 6963
RefSeq ORF 4479
Synonyms MAPKKK1; Mekk; MEKK1
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources

file-alt Citations

Combating acquired resistance to MAPK inhibitors in melanoma by targeting Abl1/2-mediated reactivation of MEK/ERK/MYC signaling
Tripathi, Liu, Jain et al
Nat Commun (2020) 11 (1), 5463 DOI: 10.1038/s41467-020-19075-3
Cited by 51
AI Summary: OriGene’s recombinant MAP3K1 protein was used in kinase assays to investigate ABL1/2-mediated phosphorylation, helping to elucidate the molecular mechanisms underlying resistance to MAPK inhibitors in melanoma.
Snippet: … Incubation of MAP3K1 with ABL1 or ABL2 results in modest tyrosine phosphorylation of full-length MAP3K1 (Fig. 7c). The supplied recombinant MAP3K1 has some degradation products (see Origene website). Interestingly, ABL1 efficiently phosphorylates the 80 kDa breakdown product, whereas ABL1 and ABL2 phosphorylate a 100 kDa breakdown product recognized by a C-terminal MAP3K1 ant;. The supplied recombinant MAP3K1 has some degradation products (see Origene website). Interestingly, ABL1 efficiently phosphorylates the 80 kDa breakdown product, whereas ABL1 and ABL2 phosphorylate a 100 kDa breakdown product recognized by a C-terminal MAP3K1 antibody (Fig. 7d, left and Supplementary Fig. 7a, left)
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products