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Ipo4 (NM_024267) Mouse Recombinant Protein

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SKU
TP520703
Purified recombinant protein of Mouse importin 4 (Ipo4), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Size:
20 ug
  $1,020.00
4 Weeks*
Bulk/Customize

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Specifications
Specifications
Product Data
Species Mouse
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
>MR220703 representing NM_024267
Red=Cloning site Green=Tags(s)

MEPAGLEQILKELLLPDTERIRRATEQLQTILRDPAALPALFDLLATATDSQIRQFAAVLTRRRLNNRWR
RLAPEQRESLKSLVLTALQKETVHSVSVSLAQLSATIFRKEGLQGWPQFMNLLQHSTHSSHSPEKEVGLL
LLSVVVSSQPEAFHAHQHELLQLLNETLSDVSFPGVLFYSLRTLTAIARYVRPDDVSLARMLVPKVVTAL
RTLIPLDEVKACEALEALDEMLETELPIINPHLSEVLTFCLEVAKNVALGEPLRVRVLCCLTFLVKVKSK
ALLKNRLVPPLLHALFPLMAAEPPMGQLDPEDQDSDDDDLEIGLMGETPKHFAVQVVDMLALHLPPEKLC
PHVMPMLEEALRSEDPYQRKAGFLVLAVLSDGAGDHIRQRLLYPLLQIVCKGLDDPSQIVRNAALFALGQ
FSENLQPHISSYSEEVMPLLLSYLKSVPMGNTHHLAKACYALENFVENLGPKVQPYLPELMECMLQPLKN
PSKARTKELAVSAIGAIATAAQDSLLPYFPTIMDLLREFLLTGHEDFHLVQIQSLETLGVLARALGESMK
PLAEECCQLGLGLCIHIDDPDVRRCTYSLFAALSGLMGEGLGPYLPQITTLMLLSLRSTEGIVPQYDGIS
SFLLFDDDSEAEEEEELMDEDMEEEGDDSEISGYSVENAFFDEKEDTCTALGEISMNTCVAFLPFMDATF
DEVYKLLECPHMNVRKSAYEALGQFCCALHKASQRSSSDPSSSPVLQTSLARVMPAYMQAVKVERERPVV
MAVLESLTGVLRTCGSLALQPPGRLSELCNVLKAVLQKKTACQDAEEDDDEDDDQAEYDAMLLEHAGEAI
PVLAATAGGHAFAPFFATFLPLLLCKTKQSCTVAEKSFAVGTLAESIQGLGTASAQFVSRLFPVLLNNAR
EADPEVRSNAIFGLGVLAEHGGCPAQDHFPKLLGLLLPLLARERHDRVRDNICGALARVLMASPVGKTEP
QVLATLLRALPLKEDMEEWLTIGHLFSFLHQNNPEQVVDVASELLRICSLILPDNRIPPDTKAALLLLLT
FLAKQHTDSFHTALGSLPNDKAQELQAMMGLT

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag C-MYC/DDK
Predicted MW 119.3 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C after receiving vials.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_077229
Locus ID 75751
UniProt ID Q8VI75
Cytogenetics 14 28.19 cM
RefSeq Size 3611
RefSeq ORF 3246
Synonyms 8430408O15Rik; AA409693; Imp4a; RanBP4
Summary Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. Acts as chaperone for exposed basic domains.UniProtKB/Swiss-Prot Function
Protein Categories Intracellular Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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