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Phlpp2 (NM_001122594) Mouse Recombinant Protein

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SKU
TP519729
Purified recombinant protein of Mouse PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Size:
20 ug
  $1,020.00
4 Weeks*
Bulk/Customize

Frequently Bought Together (1)

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Specifications
Specifications
Product Data
Species Mouse
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
>MR219729 representing NM_001122594
Red=Cloning site Green=Tags(s)

MGEVEPVPAGPLEPPEPPEAAAPRRPGGIRVLKRNMKHNGSRTCLNRRSRFGSRERDWLREDVKRGCVYL
YGADTTTATTTTSSSSSSSSSSDLHLVLCTVETPASEICAGEGRESLYLQLHGDLVRRLEPSERPLQIVY
DYLSRLGFEDPVRIQEEATNPDLSCMIRFYGEKPCQMDHLDRILLSGIYNVRKGKTQLHKWAERLVVLCG
TCLIVSSVKDCQTGKMHILPLVGGKIEEVKRRQHSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVS
QRMSTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLHKFSQLKGLNLSHNKLGLFPVLL
CEISTLTELSLSCNGFHDLPSQIGKLLNLQTLSLDGNGLTALPDELGNLRQLTSLGISFNDFRHIPEVLE
KLTMLDKVAMAGNRLEVLNLGALTRMSQVKHVDLRMNHLKTVITENMEGNKHITHMDLRDNQLTDLDLSS
LCSLEQLHCERNQLRELTLSGFSLRTLYASWNRLTAVNVYPVPSLLTSLELSQNLLECVPDWACEAKKLE
ILDISHNLLTEVPMRILSSLSLRKLMVGHNHIHVLPALVEHIPLEVLDIQHNTLSRLPDTLFSKALNLRY
LNASANSLESLPSACAGEESLSVLQLLYLTSNLLTDQCIPVLVGHPHLRVLHLANNQLQTFPASKLNKLE
QLEELNLSGNKLTAIPTTIANCKRLHTLVAHANNISIFPEILQLPQIQFVDLSCNDLTEILIPEALPATL
QDLDLTGNTNLVLEHKTLDMFSHITALKIDQKPLPATDSAVTSTFWSHGLAEMAGQRNKLCVSALAMDNF
AEGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEVQHSTNDTVFMTNTFLVSHRKLGMAGQKLGSSALLC
YIRPDTADPTSSFSLTVANVGMCQAVLCRGGKPVPLSKVFSLEHDPEEAQRVKDQKAIITEDNKVNGVTC
CTRLLGCTYLYPWILPKPHIASTPLTIQDELLILGNKALWEHLSYLEAVNAVRHVQDPLAAAKKLCTLAQ
SYGCQDNVGAMVVYLNIGEEGCTCEMNGLTLPGPVGFASTAALKDTPKPTTPSSSSGIASEFSSEMSTSE
VSSEVGSTASDEHNTVGLEASLLPRPERRCSLHPASSAGVFQRQPSCATFSSNQSDNGLDSDDDQPVEGV
ITNGSRVEVEVDIHCCRGREPESSPPLPKNSSNACSEERARGAGFGIRRQNSVNSGILLPANRDKMELQK
SPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEAPKRKTGYFAAPTQLEPEDQFVVPRDLEEEVKEQMKQH
QEGRPEPEPRGEERTEPLEEFDTAL

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag C-MYC/DDK
Predicted MW 150.1 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C after receiving vials.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_001116066
Locus ID 244650
UniProt ID Q8BXA7
Cytogenetics 8 D3
RefSeq Size 7854
RefSeq ORF 4065
Synonyms AI481772; C130044A18Rik; Phlppl
Summary Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis. Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (By similarity).UniProtKB/Swiss-Prot Function
Protein Categories Cytokines, Intracellular Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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