Xrn2 (NM_011917) Mouse Recombinant Protein

CAT#: TP511279

Purified recombinant protein of Mouse 5'-3' exoribonuclease 2 (Xrn2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Specifications

Product Data

• Description: Purified recombinant protein of Mouse 5'-3' exoribonuclease 2 (Xrn2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
• Species: Mouse
• Expression Host: HEK293T
• Expression cDNA Clone or AA Sequence: A DNA sequence from Mouse cDNA ORF Clone, MR211279, encoding Mouse full-length Xrn2.
• Tag: C-MYC/DDK
• Predicted MW: 108.7 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_036047
• Locus ID: 24128
• Refseq Size: 3383
• Cytogenetics: 2 G2
• Refseq ORF: 2856
• Summary: Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (By similarity).[UniProtKB/Swiss-Prot Function]