Xrn2 (NM_011917) Mouse Recombinant Protein

CAT#: TP511279

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Purified recombinant protein of Mouse 5'-3' exoribonuclease 2 (Xrn2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug



USD 748.00


Availability*
4 Weeks

Size
    • 20 ug


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Specifications

Product Data
Description Purified recombinant protein of Mouse 5'-3' exoribonuclease 2 (Xrn2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Species Mouse
Expression Host HEK293T
Expression cDNA Clone or AA Sequence A DNA sequence from Mouse cDNA ORF Clone, MR211279, encoding Mouse full-length Xrn2.
Tag C-MYC/DDK
Predicted MW 108.7 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Storage Store at -80°C after receiving vials.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_036047
Locus ID 24128
Refseq Size 3383
Cytogenetics 2 G2
Refseq ORF 2856
Summary Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (By similarity).[UniProtKB/Swiss-Prot Function]

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