Arnt (NM_001037737) Mouse Recombinant Protein
SKU
TP510673
Purified recombinant protein of Mouse aryl hydrocarbon receptor nuclear translocator (Arnt), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
$1,020.00
4 Weeks*
Specifications
| Product Data | |
| Species | Mouse |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-MYC/DDK |
| Predicted MW | 87 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C after receiving vials. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_001032826 |
| Locus ID | 11863 |
| UniProt ID | P53762 |
| Cytogenetics | 3 40.74 cM |
| RefSeq Size | 4370 |
| RefSeq ORF | 2373 |
| Synonyms | bHLHe2; D3Ertd557e; Drnt; ESTM42; Hif1b; mKIAA4051; W08714 |
| Summary | Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (PubMed:26245371, PubMed:27782878). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).UniProtKB/Swiss-Prot Function |
| Protein Categories | Growth Factors, Intracellular Proteins, Transciption Factors |
Reviews
Documents
| FAQs |
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Resources
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Citations
The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
Apetoh, Quintana, Pot et al
Nat Immunol (2010) 11 (9), 854-61 DOI: 10.1038/ni.1912
Apetoh, Quintana, Pot et al
Nat Immunol (2010) 11 (9), 854-61 DOI: 10.1038/ni.1912
Cited by 730
AI Summary: OriGene products contributed to this study by providing the c-Maf expression plasmid (RC211218) and c-Maf shRNA (TL313386), which were used to manipulate c-Maf levels and investigate its interaction with the aryl hydrocarbon receptor in the differentiation of type 1 regulatory T cells.
Showing 1-1 of 1 papers.
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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