Ttll12 (NM_183017) Mouse Recombinant Protein

SKU TP509682

Purified recombinant protein of Mouse tubulin tyrosine ligase-like family, member 12 (Ttll12), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Product Data

• Species: Mouse
• Expression Host: HEK293T
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  >MR209682 protein sequence; Red=Cloning site Green=Tags(s); ; MEIQSGPQPGSPGRAERLNARLLDEFVSLHGPTLRASGVPERLWGRLLHKLEHEVFDAGEMFGIKQVEEV; EEAEDEAAREAQRKQPNPGGELCYKVIVTSESGVRADDPNSIFLIDHAWTCRVEHARKQLQQVPGLLHRM; ANLMGIEFHGEVPSPEVVALVLEEMWKFNQTYQLAHGTAEEKVPVWYIMDEFGSRIQHSDMPSFATAPFF; YMPQQVAYTLLWPLRDLDTGEEVTRDFAYGEADPLIRKCMLLPWAPADMLDLSFSTPEPPAKYYQAILEE; NKEKLPLAISPVARPQGHVFRVHCDVQQVLGHLTHPRFTFTDSEADADIFFHFSHFKDYMKLSQESPQVL; LNQFPCENLLTVKDCLASIARRAGGPEGPPWLPRTFNLRTELPQFVSYFQHRERRGEDNHWICKPWNLAR; SLDTHVTNNLHSIIRHRESTPKVVSKYIESPVLFLREDVGNVKFDIRYIVLLRSVRPLRLFAYDVFWLRF; SNRPFALDDLDDYEKHFTVMNYDPDVVLKQVHYNEFIPQFEKQYPEFPWSDVQAEIFKAFTELFQVACAK; PPPMGLCDYPSSRAMYAIDLMLNWDNHPDGKRVMQPQILEVNFNPDCERACRYHPSFFNDVFSTLFLDET; DNCHVTRII; ; TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Tag: C-MYC/DDK
• Predicted MW: 74 kDa
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Shipping: Dry Ice

Reference Data

• RefSeq: NP_898838
• Locus ID: 223723
• UniProt ID: Q3UDE2
• Cytogenetics: 15 E1
• RefSeq Size: 3770
• RefSeq ORF: 1917
• Synonyms: BC055368; D430005B17
• Summary: Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.[UniProtKB/Swiss-Prot Function]