Glmn (NM_133248) Mouse Recombinant Protein

SKU
TP509268
Purified recombinant protein of Mouse glomulin, FKBP associated protein (Glmn), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
  $1,020.00
4 Weeks*
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Specifications
Specifications
Product Data
Species Mouse
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
>MR209268 representing NM_133248
Red=Cloning site Green=Tags(s)

MAVEELQSIIKRCQILEEHDFKEEDFGLFQLAGQRCIEDGYINQLLEIIQDEKNKTIIKSMGWNLVGPVV
RCLLRGREEDKREECFLIFDLLVKLCNPKELLLGLLELIEEPSGKQISQIILLLLQPLQTVIQKLPNNKA
YSVGLALSTLWSQLSLLPVPHSEEQIQADDYGLCQCCKALIEFTKPFVEEVISDKENKENAKLKDELLKF
CFKGLKCPLLTAQFLEQSEDVGNDPFRCFASEIIGFLSKIGHPVPQIILNHGRKKRTWDYLEFEEEEDKQ
LAESVASLTYLVFVQGIGIDQLPMVLSPSYLLQLNMEHIEVFLQRTEQSIYSKGLELLETSLLRLEDNSL
CYQYLEIKSFLAVPQGLVKVMTLCPIETLRKKGLSMLQLFIDKLDSQGKYTLFRCLLNTSNHSGVEAFVI
QNIKNQIDLSFKKTYNKWFAGAQLISLLDLVLSLPEGAETDLLQNSDRIMASLNLLRYLVIKDNEDDNQT
GLWTELGKIENNFLKPLHIGLNMSKAHYEAEIKNSQQNNQVASMCKGVCSVTVGGEEIPSMPPEMQLKVL
HSALFTFDLIESVLARVEELIEIKSKSTSEENVGIK

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag C-MYC/DDK
Predicted MW 68.2 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C after receiving vials.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_573511
Locus ID 170823
UniProt ID Q8BZM1
Cytogenetics 5 E5
RefSeq Size 2015
RefSeq ORF 1788
Synonyms 9330160J16Rik; AW227515; Fap48; Fap68
Summary Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes. Inhibits E3 ubiquitin ligase activity by binding to the RING domain of RBX1 and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34. Inhibits RBX1-mediated neddylation of CUL1 (By similarity). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (PubMed:22405651). Essential for normal development of the vasculature (PubMed:22405651). Contributes to the regulation of RPS6KB1 phosphorylation (By similarity).UniProtKB/Swiss-Prot Function
Protein Categories Cytokines, Growth Factors, Intracellular Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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