Cdyl (NM_001123386) Mouse Recombinant Protein
SKU
TP508673
Purified recombinant protein of Mouse chromodomain protein, Y chromosome-like (Cdyl), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
$1,020.00
In Stock*
Specifications
| Product Data | |
| Species | Mouse |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-MYC/DDK |
| Predicted MW | 60.1 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C after receiving vials. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_001116858 |
| Locus ID | 12593 |
| UniProt ID | Q9WTK2 |
| Cytogenetics | 13 14.39 cM |
| RefSeq Size | 3494 |
| RefSeq ORF | 1632 |
| Synonyms | AI325931 |
| Summary | Isoform 2: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:12947414). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:12947414). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (By similarity). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (By similarity). Involved X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (PubMed:24144980). Required for neuronal migration during brain development by repressing expression of RHOA (PubMed:28076783). In addition to act as a chromatin reader, acts as a hydro-lyase (By similarity). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (By similarity). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (PubMed:28803779). May have histone acetyltransferase activity; such activity is however unsure in vivo (PubMed:12072557).UniProtKB/Swiss-Prot Function |
| Protein Categories | Intracellular Proteins |
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Citations
Interaction between Chromodomain Y-like Protein and Androgen Receptor Signaling in Sertoli Cells Accounts for Spermatogenesis
Lan, Cheng, Chang et al
Cells (2024) 13 (10) DOI: 10.3390/cells13100851
Lan, Cheng, Chang et al
Cells (2024) 13 (10) DOI: 10.3390/cells13100851
Cited by 6
AI Summary: OriGene’s CDYL recombinant protein (TP508673) was used in this study to investigate the mRNA expression of AR, CDYL, and TNP1, thereby facilitating analysis of the molecular interactions underlying spermatogenesis in Sertoli cells.
Snippet: … The mouse CDYL overexpression plasmid was obtained from GenScript (Piscataway, NJ, USA). CDYL recombinant proteins were sourced from OriGene (TP508673, Rockville, MD, USA) to investigate the mRNA expression of AR, CDYL, and TNP1. TM4 cells were transfected to overexpress AR and CDYL for luciferase assays. …
Showing 1-1 of 1 papers.
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