Fus (NM_139149) Mouse Recombinant Protein
SKU
TP508306
Purified recombinant protein of Mouse fused in sarcoma (Fus), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
$1,020.00
4 Weeks*
Specifications
| Product Data | |
| Species | Mouse |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-MYC/DDK |
| Predicted MW | 53.1 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C after receiving vials. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_631888 |
| Locus ID | 233908 |
| UniProt ID | P56959 |
| Cytogenetics | 7 F3 |
| RefSeq Size | 1845 |
| RefSeq ORF | 1554 |
| Synonyms | D430004D17Rik; D930039C12Rik; Fus1; Tls |
| Summary | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (By similarity). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (PubMed:16317045, PubMed:25968143).UniProtKB/Swiss-Prot Function |
| Protein Categories | Intracellular Proteins, Nervous system: Neurodegenerative diseases |
Reviews
Documents
| FAQs |
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Resources
| Recombinant Protein Resources |
Citations
Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways
Blokhuis, Koppers, Groen et al
Acta Neuropathol. (2016)
Blokhuis, Koppers, Groen et al
Acta Neuropathol. (2016)
Cited by 146
AI Summary: OriGene's recombinant FUS protein was used in this study to investigate direct and RNA-dependent interactions between ALS-associated proteins and FMRP, helping to elucidate converging molecular pathways in ALS pathogenesis.
Snippet: Precipitated proteins were eluted by boiling in NuPage LDS sample buffer containing 10 mM DTT for 5 min at 90 °C. For RNA dependency experiments, lysates were first treated with RNAse A (Roche) for 30 min at 4 °C. Recombinant FUS (Origene) and FMRP (Abnova ... Cite SaveSaving
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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