Mapk13 (NM_011950) Mouse Recombinant Protein

CAT#: TP505630

Reviews ()
Write a review

Purified recombinant protein of Mouse mitogen-activated protein kinase 13 (Mapk13), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug



USD 748.00


Availability*
4 Weeks

Size
    • 20 ug


Product images

Specifications

Product Data
Description Purified recombinant protein of Mouse mitogen-activated protein kinase 13 (Mapk13), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Species Mouse
Expression Host HEK293T
Expression cDNA Clone or AA Sequence A DNA sequence from Mouse cDNA ORF Clone, MR205630, encoding Mouse full-length Mapk13.
Tag C-MYC/DDK
Predicted MW 42.1 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Storage Store at -80°C after receiving vials.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_036080
Locus ID 26415
Refseq Size 1406
Cytogenetics 17 A3.3
Refseq ORF 1101
Synonyms SAPK4; Serk4
Summary Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.[UniProtKB/Swiss-Prot Function]

Documents

Other products for "Mapk13"
Frequently bought together (1)
Clone OTI4C5, Anti-DDK (FLAG) monoclonal antibody
    • 100 ul

USD 350.00

Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
68 Mouse Clones
Molbio tools
HUMAN PROREINS 101