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Cd63 (BC089543) Mouse Recombinant Protein

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SKU
TP502911
Purified recombinant protein of Mouse Cd63 antigen (cDNA clone MGC:107286 IMAGE:30284264), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Size:
20 ug
  $1,020.00
4 Weeks*
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Specifications
Specifications
Product Data
Species Mouse
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence from Mouse cDNA ORF Clone, MR202911, encoding Mouse full-length Cd63.
Tag C-MYC/DDK
Predicted MW 41.3 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C after receiving vials.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
Locus ID 12512
UniProt ID P41731
Cytogenetics 10 77.19 cM
RefSeq Size 1127
RefSeq ORF 714
Synonyms ME491, Tspan30
Summary Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.UniProtKB/Swiss-Prot Function
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Documents
Resources

file-alt Citations

The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting
Mamo, Jules, Dumaresq-Doiron et al
Mol. Cell. Biol. (2012) 32 (10), 1855-66 DOI: 10.1128/MCB.06726-11
Cited by 7
AI Summary: OriGene products contributed to this study by providing the cDNA for CLN1 and myc-CD63, which were used to investigate the role of CLN5 in endosomal sorting and lysosomal receptor trafficking.
Snippet: The cDNA for CLN1 and myc-CD63 was purchased from Origene (Rockville, MD). ... To deplete sortilin, HeLa cells were transfected using short hairpin sortilin (shSortilin) and Lipofectamine reagent according to the instructions of the manufacturer (Invitrogen, Burlington, Ontario
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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