HIC1 (NM_006497) Human Recombinant Protein
SKU
TP322752M
Purified recombinant protein of Homo sapiens hypermethylated in cancer 1 (HIC1), transcript variant 1, 100 µg
$2,950.00
4 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 74.3 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_006488 |
| Locus ID | 3090 |
| UniProt ID | Q14526 |
| Cytogenetics | 17p13.3 |
| RefSeq Size | 2626 |
| RefSeq ORF | 2142 |
| Synonyms | hic-1; ZBTB29; ZNF901 |
| Summary | This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. provided by RefSeq, Sep 2010 |
| Protein Categories | Growth Factors, Intracellular Proteins, Transciption Factors |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
Liu, Helenius, Skotte et al
Nat Commun (2019) 10 (1), 3927 DOI: 10.1038/s41467-019-11881-8
Liu, Helenius, Skotte et al
Nat Commun (2019) 10 (1), 3927 DOI: 10.1038/s41467-019-11881-8
AI Summary: OriGene’s recombinant human HIC1 purified protein (Cat# TP322752, expressed in HEK293 using TrueORF clone RC222752) was used in EMSA experiments to assess how the rs7594852 variant affects HIC1 binding, helping clarify the functional mechanism underlying the genetic association with gestational duration.
Snippet: EMSAs were performed to determine whether the rs7594852 polymorphism at the 2q13 locus differentially affected HIC1 binding. Recombinant human HIC1 purified protein (ORIGENE #TP322752) was obtained from ORIGENE (expressed in HEK293 using TrueORF clone, RC222752) with a c-Myc/DDK tag
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration
Liu, Helenius, Skotte et al
bioRxiv (2018)
Liu, Helenius, Skotte et al
bioRxiv (2018)
Snippet: … Beaumont4, Matthias Wielscher5 View as HTML;EMSAs were performed to determine whether the rs7594852 polymorphism at the 2q13 locus differentially affected HIC1 binding. Recombinant human HIC1 purified protein (ORIGENE #TP322752) was obtained from ORIGENE (expressed in HEK293 using TrueORF clone, RC222752) with a c-Myc/DDK tag. Double-stranded IRDye700 5’ end-labelled 39 bp oligonucleotides, identical except for the nucleotide at rs7594852 (either the “C” or “T” allele), were obtained from IDT. …
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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