Tyrosinase (TYR) (NM_000372) Human Recombinant Protein
SKU
TP321797
Purified recombinant protein of Homo sapiens tyrosinase (affected in Oculocutaneous Albinism IA) (TYR), 20 µg
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 60.4 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_000363 |
| Locus ID | 7299 |
| UniProt ID | P14679 |
| Cytogenetics | 11q14.3 |
| RefSeq Size | 1964 |
| RefSeq ORF | 1587 |
| Synonyms | ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3 |
| Summary | The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. provided by RefSeq, Oct 2008 |
| Protein Categories | Membrane Proteins |
| Protein Families | Transmembrane |
| Protein Pathways | Melanogenesis, Metabolic pathways, Riboflavin metabolism, Tyrosine metabolism |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "Tyrosinase" proteins (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH321797 | TYR MS Standard C13 and N15-labeled recombinant protein (NP_000363) | 10 ug |
$3,360.00
|
|
| LC424756 | Lyophilized TYR HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY424756 | Transient overexpression lysate of tyrosinase (affected in oculocutaneous albinism IA) (TYR) (as WB positive control) | 100 ug |
$665.00
|
|
| TP762332 | Purified recombinant protein of Human tyrosinase (affected in oculocutaneous albinism IA) (TYR), His19-Phe320, with N-terminal His tag, expressed in E.coli, 50ug | 50 ug |
$260.00
|
|
Citations
Flavonoids, Hydroxycinnamates, and Phenolamides of Phacelia tanacetifolia Benth. (Boraginaceae) Herb
Olennikov, Kornopoltseva, Losonogova et al
Pharmaceutical Chemistry Journal (2026) 59 (10), 1125-1133 DOI: 10.1007/s11094-026-03501-9
Olennikov, Kornopoltseva, Losonogova et al
Pharmaceutical Chemistry Journal (2026) 59 (10), 1125-1133 DOI: 10.1007/s11094-026-03501-9
Cited by 1
AI Summary: OriGene’s human recombinant tyrosinase (SKU TP321797) was used in this study to evaluate the effects of Phacelia tanacetifolia compounds on tyrosinase activity.
Snippet: Antityrosinase activity. The effects of individual compounds on tyrosinase activity was studied by spectrophotometry using a Tyrosinase Assay Kit (Sigma-Aldrich, No. MAK550) and three enzymes, including fungal tyrosinase (Sigma-Aldrich, No. T3824, 100 U/mg), human recombinant tyrosinase (oculocutaneous albinism type IA;OriGene Technologies, Inc., No. SKU TP321797, 0.05 μg/mL
Oxyresveratrol suppressed melanogenesis, dendrite formation, and melanosome transport in melanocytes via regulation of the MC1R/cAMP/MITF pathway
Zhang, Liu, Guo et al
Sci Rep (2025) 15 (1), 20400 DOI: 10.1038/s41598-025-05248-x
Zhang, Liu, Guo et al
Sci Rep (2025) 15 (1), 20400 DOI: 10.1038/s41598-025-05248-x
Cited by 4
AI Summary: OriGene’s recombinant human tyrosinase (TP321797L) was used in this study to assess the inhibitory effects of oxyresveratrol on tyrosinase activity, contributing to the investigation of its antimelanogenic properties.
Snippet: was purchased from MACKLIN (China). Glabridin (CAS: 59870-68-7, SG8480, purity ≥ 98%) and PBS buffer were purchased from Solarbio (China). Recombinant human tyrosinase (TP321797L) was obtained from OriGene (USA). L-DOPA (CAS: 59-92-7, S20191, purity ≥ 99%) was purchased from Shanghai Yuanye Bio-Technology (China). Dulbecco’s modified Eagle medium (DMEM, 2105341) was purchased from Gibco (USA
Unveiling the Metabolites Underlying the Skin Anti-Ageing Properties of Cytinus hypocistis (L.) L. through a Biochemometric Approach
Silva, Ayuso, García et al
Phytomedicine (2024)
Silva, Ayuso, García et al
Phytomedicine (2024)
Cited by 4
AI Summary: OriGene's human tyrosinase enzyme (TP321797) was used in this study to assess the inhibitory effects of Cytinus hypocistis metabolites on skin-related enzymatic activity, contributing to the evaluation of the plant's anti-ageing properties.
Snippet: The human tyrosinase enzyme (TP321797, Origene) was diluted to 2 µg/mL with the recommended buffer (25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol). Before
Showing 1-3 of 3 papers.
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