CD11a (ITGAL) (NM_002209) Human Recombinant Protein
SKU
TP321297
Recombinant protein of human integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) (ITGAL), transcript variant 1, 20 µg
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 126.1 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Bioactivity | Far-Western blot (PMID: 26600301) |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_002200 |
| Locus ID | 3683 |
| UniProt ID | P20701 |
| Cytogenetics | 16p11.2 |
| RefSeq Size | 5133 |
| RefSeq ORF | 3510 |
| Synonyms | CD11A; LFA-1; LFA1A |
| Summary | ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2008 |
| Protein Categories | CD Markers, Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Regulation of actin cytoskeleton, Viral myocarditis |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "CD11a" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH321297 | ITGAL MS Standard C13 and N15-labeled recombinant protein (NP_002200) | 10 ug |
$3,360.00
|
|
| LC400809 | Lyophilized ITGAL HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY400809 | Transient overexpression lysate of integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) (ITGAL), transcript variant 1 (as WB positive control) | 100 ug |
$665.00
|
|
Citations
The effect of ADAMTS13 on graft-versus-host disease
Li, Cho, Gonzalez-Delgado et al
J Cell Mol Med (2024) 28 (13), e18457 DOI: 10.1111/jcmm.18457
Li, Cho, Gonzalez-Delgado et al
J Cell Mol Med (2024) 28 (13), e18457 DOI: 10.1111/jcmm.18457
Cited by 4
AI Summary: In this study, OriGene's Integrin αL protein (catalogue # TP321297) was used to investigate the interaction between T cells and Von Willebrand factor, helping to elucidate the mechanism by which ADAMTS13 and VWF-A2 peptide reduce graft-versus-host disease severity.
Snippet: e surface was then treated with 0.1% SDS to remove loosely bound A2 (final density ~ 1200 RU). Integrin αL stock solution (0.16 mg/mL in 25 mM Tris, 100 mM glycine, 10% glycerol, pH 7.3. Origene, catalogue # TP321297) was diluted to 16 ug/mL in 10 mM sodium acetate (pH 5.0) for immobilization (final surface density ~ 500 RU). A reference surface was made with activation and de
Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling
De Franceschi, Peuhu, Parsons et al
PLoS ONE (2015) 10 (11), e0143423 DOI: 10.1371/journal.pone.0143423
De Franceschi, Peuhu, Parsons et al
PLoS ONE (2015) 10 (11), e0143423 DOI: 10.1371/journal.pone.0143423
Cited by 24
AI Summary: OriGene contributed recombinant full-length human ITGAL-ITGB2 protein to this study, which was used to investigate the interactions between SHARPIN and integrins.
Snippet: obtained from Lifetein. The membrane-permeable ITGA1-tail peptide (α1-TAT) and scrambled peptide (ScrTAT) were from Lifetein. Recombinant full-length human ITGAL-ITGB2 was from Origene. Recombinant GST-RNF31 ... Cite SaveSaving
Showing 1-2 of 2 papers.
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