APOBEC3A (NM_145699) Human Recombinant Protein
SKU
TP320995L
Purified recombinant protein of Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (APOBEC3A), 1 mg
$7,820.00
6 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 22.8 kDa |
| Concentration | >0.1 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_663745 |
| Locus ID | 200315 |
| UniProt ID | P31941 |
| Cytogenetics | 22q13.1 |
| RefSeq Size | 1349 |
| RefSeq ORF | 597 |
| Synonyms | A3A; ARP3; bK150C2.1; PHRBN |
| Summary | This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jul 2012 |
| Protein Categories | Intracellular Proteins |
Reviews
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Resources
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Citations
APOBEC3A regulates transcription from interferon-stimulated response elements
Taura, Frank, Takahashi et al
Proc Natl Acad Sci U S A (2022) 119 (20), e2011665119 DOI: 10.1073/pnas.2011665119
Taura, Frank, Takahashi et al
Proc Natl Acad Sci U S A (2022) 119 (20), e2011665119 DOI: 10.1073/pnas.2011665119
Cited by 23
Apobec3A maintains HIV-1 latency through recruitment of epigenetic silencing machinery to the long terminal repeat
Taura, Song, Ho et al
PNAS (2019) 116 (6), 2282-2289 DOI: 10.1073/pnas.1819386116
Taura, Song, Ho et al
PNAS (2019) 116 (6), 2282-2289 DOI: 10.1073/pnas.1819386116
AI Summary: OriGene’s recombinant A3A protein (TP320995) was used in this study to investigate the role of Apobec3A in maintaining HIV-1 latency through recruitment of epigenetic silencing machinery.
Snippet: …Log in;Log out;My Cart. Main menu;Dynabeads Protein G, Dynabeads Human T-Activator CD3/CD28 (CD3/28-Dynabeads), and Dynabeads M-280 Streptavidin were purchased from Thermo Fisher Scientific. Recombinant A3A (TP320995) was purchased from OriGene
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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