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INPP5F (OCRL) (NM_000276) Human Recombinant Protein

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SKU
TP320672
Recombinant protein of human oculocerebrorenal syndrome of Lowe (OCRL), transcript variant a, 20 µg
Size:
20 ug 1 mg 100 ug
  $737.00
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
>RC220672 representing NM_000276
Red=Cloning site Green=Tags(s)

MEPPLPVGAQPLATVEGMEMKGPLREPCALTLAQRNGQYELIIQLHEKEQHVQDIIPINSHFRCVQEAEE
TLLIDIASNSGCKIRVQGDWIRERRFEIPDEEHCLKFLSAVLAAQKAQSQLLVPEQKDSSSWYQKLDTKD
KPSVFSGLLGFEDNFSSMNLDKKINSQNQPTGIHREPPPPPFSVNKMLPREKEASNKEQPKVTNTMRKLF
VPNTQSGQREGLIKHILAKREKEYVNIQTFRFFVGTWNVNGQSPDSGLEPWLNCDPNPPDIYCIGFQELD
LSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMG
KMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWL
GDLNYRLCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSG
KCRVPAWCDRILWRGTNVNQLNYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDSVRIMDRMEND
FLPSLELSRREFVFENVKFRQLQKEKFQISNNGQVPCHFSFIPKLNDSQYCKPWLRAEPFEGYLEPNETV
DISLDVYVSKDSVTILNSGEDKIEDILVLHLDRGKDYFLTISGNYLPSCFGTSLEALCRMKRPIREVPVT
KLIDLEEDSFLEKEKSLLQMVPLDEGASERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIID
CLDTSIPETIPGSNHSVAEALLIFLEALPEPVICYELYQRCLDSAYDPRICRQVISQLPRCHRNVFRYLM
AFLRELLKFSEYNSVNANMIATLFTSLLLRPPPNLMARQTPSDRQRAIQFLLGFLLGSEED

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag C-Myc/DDK
Predicted MW 104 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Bioactivity Enzyme activity (PMID: 29524543)
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_000267
Locus ID 4952
UniProt ID Q01968
Cytogenetics Xq26.1
RefSeq Size 5165
RefSeq ORF 2703
Synonyms Dent-2; DENT2; INPP5F; LOCR; NPHL2; OCRL-1; OCRL1
Summary This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. provided by RefSeq, Jan 2016
Protein Categories Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system
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Other "INPP5F" proteins (7)
SKU Description Size Price
PH310491 OCRL MS Standard C13 and N15-labeled recombinant protein (NP_001578) 10 ug
$3,360.00
PH320672 OCRL MS Standard C13 and N15-labeled recombinant protein (NP_000267) 10 ug
$3,360.00
LC400105 Lyophilized OCRL HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC419853 Lyophilized OCRL HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400105 Transient overexpression lysate of oculocerebrorenal syndrome of Lowe (OCRL), transcript variant a (as WB positive control) 100 ug
$665.00
LY419853 Transient overexpression lysate of oculocerebrorenal syndrome of Lowe (OCRL), transcript variant b (as WB positive control) 100 ug
$436.00
TP310491 Recombinant protein of human oculocerebrorenal syndrome of Lowe (OCRL), transcript variant b, 20 µg 20 ug
$737.00

file-alt Citations

A phosphoglycolate phosphatase/AUM-dependent link between triacylglycerol turnover and epidermal growth factor signaling
Segerer, Engelmann, Kaestner et al
Biochim. Biophys. Acta (2018) 1863 (6), 584-594 DOI: 10.1016/j.bbalip.2018.03.002
Snippet: reaction buffer (30 mM triethanolamine, 5 mM MgCl 2 , 30 mM NaCl, 0.1% Triton X-100 and 5 mM DTT, pH 7.5) for 60 min at 37 °C. The activity of purified human inositol polyphosphate 5′-phosphatase oculocerebrorenal syndrome of Lowe (OCRL;OriGene
Showing 1-1 of 1 papers.
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