Junctophilin 2 (JPH2) (NM_020433) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 74 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_065166 |
| Locus ID | 57158 |
| UniProt ID | Q9BR39 |
| Cytogenetics | 20q13.12 |
| RefSeq Size | 4802 |
| RefSeq ORF | 2088 |
| Synonyms | CMH17; JP-2; JP2 |
| Summary | Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. provided by RefSeq, Jul 2008 |
| Protein Categories | Cardiovascular diseases, Intracellular Proteins, Membrane Proteins |
| Protein Families | Transmembrane |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "Junctophilin 2" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH319661 | JPH2 MS Standard C13 and N15-labeled recombinant protein (NP_065166) | 10 ug |
$3,360.00
|
|
| LC412483 | Lyophilized JPH2 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY412483 | Transient overexpression lysate of junctophilin 2 (JPH2), transcript variant 1 (as WB positive control) | 100 ug |
$665.00
|
|
Citations
Matrix metalloproteinase inhibition protects against junctophilin-2 proteolysis during doxorubicin-induced cardiotoxicity
Bassiouni, Chan, Roczkowsky et al
Br J Pharmacol (2025)
Bassiouni, Chan, Roczkowsky et al
Br J Pharmacol (2025)
Cited by 3
AI Summary: OriGene’s recombinant human JPH-2 protein was used in this study to assess JPH-2 proteolysis and folding, helping to elucidate the role of matrix metalloproteinase-2 in doxorubicin-induced cardiac injury.
Snippet: To ensure JPH-2 is properly folded, 20 μg of recombinant human JPH-2 (OriGene, Rockville, MD, USA) solubilised in 111 μl solution of 10% glycerol, 25 mM Tris HCl and 100 mM glycine (pH 7.3) was mixed with 2 μl 10 mg ml−1 egg yolk phosphatidylcholine and 0.2 μl 100 mg ml−1
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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