LRP5 (NM_002335) Human Recombinant Protein

CAT#: TP318864

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Purified recombinant protein of Homo sapiens low density lipoprotein receptor-related protein 5 (LRP5)


 Product Datasheet for 'TP318864'

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USD 788.00


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Size
    • 20 ug


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Specifications

Product Data
Description Purified recombinant protein of Homo sapiens low density lipoprotein receptor-related protein 5 (LRP5)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 179 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_002326
Locus ID 4041
Refseq Size 5100
Cytogenetics 11q13.2
Refseq ORF 4845
Synonyms BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP-7; LRP7; OPPG; OPS; OPTA1; PCLD4; VBCH2
Summary This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Wnt signaling pathway

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