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TRIM58 (NM_015431) Human Recombinant Protein

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SKU
TP317706
Recombinant protein of human tripartite motif-containing 58 (TRIM58), 20 µg
Size:
20 ug 1 mg 100 ug
  $737.00
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
>RC217706 protein sequence
Red=Cloning site Green=Tags(s)

MAWAPPGERLREDARCPVCLDFLQEPVSVDCGHSFCLRCISEFCEKSDGAQGGVYACPQCRGPFRPSGFR
PNRQLAGLVESVRRLGLGAGPGARRCARHGEDLSRFCEEDEAALCWVCDAGPEHRTHRTAPLQEAAGSYQ
VKLQMALELMRKELEDALTQEANVGKKTVIWKEKVEMQRQRFRLEFEKHRGFLAQEEQRQLRRLEAEERA
TLQRLRESKSRLVQQSKALKELADELQERCQRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIP
GRRELLRKFQVDVKLDPATAHPSLLLTADLRSVQDGEPWRDVPNNPERFDTWPCILGLQSFSSGRHYWEV
LVGEGAEWGLGVCQDTLPRKGETTPSPENGVWALWLLKGNEYMVLASPSVPLLQLESPRCIGIFLDYEAG
EISFYNVTDGSYIYTFNQLFSGLLRPYFFICDATPLILPPTTIAGSGNWASRDHLDPASDVRDDHL

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag C-Myc/DDK
Predicted MW 54.6 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_056246
Locus ID 25893
UniProt ID Q8NG06
Cytogenetics 1q44
RefSeq Size 2594
RefSeq ORF 1458
Synonyms BIA2
Summary E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.UniProtKB/Swiss-Prot Function
Protein Categories Intracellular Proteins
Protein Families Druggable Genome
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Other "TRIM58" proteins (3)
SKU Description Size Price
PH317706 TRIM58 MS Standard C13 and N15-labeled recombinant protein (NP_056246) 10 ug
$3,360.00
LC402434 Lyophilized TRIM58 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY402434 Transient overexpression lysate of tripartite motif-containing 58 (TRIM58) (as WB positive control) 100 ug
$665.00

file-alt Citations

TRIM58 Restrains Intestinal Mucosal Inflammation by Negatively Regulating TLR2 in Myeloid Cells
Eyking, Ferber, Köhler et al
J. Immunol. (2019)
AI Summary: OriGene contributed to this study by providing recombinant human Myc-tagged TRIM58 protein and the Myc-tagged full-length TRIM58 (Myc-TRIM58-FL) in the pCMV6-entry vector, which were used to investigate TRIM58’s role in regulating TLR2 signaling in myeloid cells.
Snippet: control). Recombinant human Myc-tagged TRIM58 protein was obtained from OriGene InvivoGen. Human Myc- tagged full-length TRIM58 (Myc-TRIM58-FL) in the pCMV6-entry- tagged cloning vector (pCMV6) was obtained from OriGene
Showing 1-1 of 1 papers.
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