Junctional Adhesion Molecule C (JAM3) (NM_032801) Human Recombinant Protein

CAT#: TP316073

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Recombinant protein of human junctional adhesion molecule 3 (JAM3)


 Product Datasheet for 'TP316073'

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USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human junctional adhesion molecule 3 (JAM3)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 36.5 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_116190
Locus ID 83700
Refseq Size 3675
Cytogenetics 11q25
Refseq ORF 1065
Synonyms JAM-2; JAM-3; JAM-C; JAMC
Summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs), Epithelial cell signaling in Helicobacter pylori infection, Leukocyte transendothelial migration, Tight junction

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