CTNS (NM_004937) Human Recombinant Protein
SKU
TP313151
Purified recombinant protein of Homo sapiens cystinosis, nephropathic (CTNS), transcript variant 2, 20 µg
$867.00
4 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 41.6 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_004928 |
| Locus ID | 1497 |
| UniProt ID | O60931 |
| Cytogenetics | 17p13.2 |
| RefSeq Size | 2611 |
| RefSeq ORF | 1101 |
| Synonyms | CTNS-LSB; PQLC4; SLC66A4 |
| Summary | This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jul 2009 |
| Protein Categories | Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Lysosome |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "CTNS" proteins (5)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH313151 | CTNS MS Standard C13 and N15-labeled recombinant protein (NP_004928) | 10 ug |
$3,360.00
|
|
| LC417639 | Lyophilized CTNS HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC421897 | Lyophilized CTNS HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY417639 | Transient overexpression lysate of cystinosis, nephropathic (CTNS), transcript variant 2 (as WB positive control) | 100 ug |
$436.00
|
|
| LY421897 | Transient overexpression lysate of cystinosis, nephropathic (CTNS), transcript variant 1 (as WB positive control) | 100 ug |
$436.00
|
|
Citations
Development of a fibrin-mediated gene delivery system for the treatment of cystinosis via design of experiment
Graceffa
Sci Rep (2022) 12 (1), 3752 DOI: 10.1038/s41598-022-07750-y
Graceffa
Sci Rep (2022) 12 (1), 3752 DOI: 10.1038/s41598-022-07750-y
Cited by 5
AI Summary: OriGene contributed to this study by providing the pCMV6-AC-GFP and pCMV6-AC-CTNS-GFP plasmids, which were essential for evaluating gene expression and functional delivery in the development of the fibrin-mediated gene delivery system for cystinosis treatment.
Snippet: … The expression vector pCMV6-AC-GFP and the plasmid pCMV6-AC-CTNS-GFP (containing the transcript variant 2 (NM_004937) of the human CTNS, with a C-terminal TurboGFP tag, tGFP) were bought from Origene and expanded in NEB 5-alpha Competent E. coli cells (New England Biolabs). Plasmids were isolated using the GeneJET Plasmid Maxiprep Kit (ThermoFisher Scientific) and their identity was confir;- plasmid pCMV6-AC-CTNS-GFP (containing the transcript variant 2 (NM_004937) of the human CTNS, with a C-terminal TurboGFP tag, tGFP) were bought from Origene
Showing 1-1 of 1 papers.
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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