Parathyroid hormone related protein (PTHLH) (NM_002820) Human Recombinant Protein

CAT#: TP312858

Recombinant protein of human parathyroid hormone-like hormone (PTHLH), transcript variant 2, 20 µg

Product Images

Coomassie blue staining of purified PTHLH protein (Cat# TP312858). The protein was produced from HEK293T cells transfected with PTHLH cDNA clone (Cat# RC212858) using MegaTran 2.0 (Cat# TT210002).

Specifications

Product Data

• Species: Human
• Expression Host: HEK293T
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  >RC212858 representing NM_002820
  Red=Cloning site Green=Tags(s)
  
  MQRRLVQQWSVAVFLLSYAVPSCGRSVEGLSRRLKRAVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTA
  EIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQEKKK
  RRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSR
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Tag: C-Myc/DDK
• Predicted MW: 15.7 kDa
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_002811
• Locus ID: 5744
• UniProt ID: P12272, Q53XY9
• Cytogenetics: 12p11.22
• Refseq Size: 1881
• Refseq ORF: 525
• Synonyms: BDE2; HHM; PLP; PTHR; PTHRP
• Summary: The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013]
• Protein Families: Druggable Genome, Secreted Protein