IGF1 (NM_000618) Human Recombinant Protein
SKU
TP312527M
Recombinant protein of human insulin-like growth factor 1 (somatomedin C) (IGF1), transcript variant 4, 100 µg
$2,508.00
4 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 11.6 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_000609 |
| Locus ID | 3479 |
| UniProt ID | P05019 |
| Cytogenetics | 12q23.2 |
| RefSeq Size | 7260 |
| RefSeq ORF | 459 |
| Synonyms | IGF; IGF-I; IGFI; MGF |
| Summary | The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. provided by RefSeq, Sep 2015 |
| Protein Categories | Cancer: Lung, Endocrine and metabolic diseases, Growth Factors, Secreated Proteins |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein |
| Protein Pathways | Dilated cardiomyopathy, Focal adhesion, Glioma, Hypertrophic cardiomyopathy (HCM), Long-term depression, Melanoma, mTOR signaling pathway, Oocyte meiosis, p53 signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength
Schwiebert, Kühnen, Becker et al
Int J Mol Sci (2020) 21 (2) DOI: 10.3390/ijms21020463
Schwiebert, Kühnen, Becker et al
Int J Mol Sci (2020) 21 (2) DOI: 10.3390/ijms21020463
Cited by 11
AI Summary: OriGene’s recombinant human IGF1 was used to assess the functional effects of autoantibodies on IGF1 receptor activation in HepG2 cells, helping demonstrate the antagonistic activity of these autoantibodies in the study.
Snippet: Isolated immunoglobulins were added to hepatocellular liver carcinoma cells (HepG2) for 1 h in serum-free medium in the presence or absence of 1 ng/mL (fc) of recombinant human IGF1 (OriGene Technologies GmbH, Herford, Germany);- Isolated immunoglobulins were added to hepatocellular liver carcinoma cells (HepG2) for 1 h in serum-free medium in the presence or absence of 1 ng/mL (fc) of recombinant human IGF1 (OriGene Technologies GmbH, Herford, Germany)
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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