Dopamine beta Hydroxylase (DBH) (NM_000787) Human Recombinant Protein

CAT#: TP312355

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Recombinant protein of human dopamine beta-hydroxylase (dopamine beta-monooxygenase) (DBH)


Product Datasheet for 'TP312355'


  View other "DBH" proteins (5)

USD 788.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human dopamine beta-hydroxylase (dopamine beta-monooxygenase) (DBH)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 64.9 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000778
Locus ID 1621
Refseq Size 2812
Cytogenetics 9q34.2
Refseq ORF 1851
Synonyms DBM; ORTHYP1
Summary The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017]
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Metabolic pathways, Tyrosine metabolism

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Other Versions

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