DISC1 (NM_018662) Human Recombinant Protein
SKU
TP312015L
Recombinant protein of human disrupted in schizophrenia 1 (DISC1), transcript variant L, 1 mg
$7,820.00
6 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 93.4 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Bioactivity | ELISA binding assay (PMID: 26062786) |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_061132 |
| Locus ID | 27185 |
| UniProt ID | Q9NRI5 |
| Cytogenetics | 1q42.2 |
| RefSeq Size | 7069 |
| RefSeq ORF | 2562 |
| Synonyms | C1orf136; SCZD9 |
| Summary | This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. provided by RefSeq, Jul 2008 |
| Protein Categories | Intracellular Proteins |
Reviews
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Resources
| Recombinant Protein Resources |
Citations
Stimulation of Synaptic Vesicle Exocytosis by the Mental Disease Gene DISC1 is Mediated by N-Type Voltage-Gated Calcium Channels
Tang, Thevathasan, Lin et al
Front Synaptic Neurosci (2016) 8, 15 DOI: 10.3389/fnsyn.2016.00015
Tang, Thevathasan, Lin et al
Front Synaptic Neurosci (2016) 8, 15 DOI: 10.3389/fnsyn.2016.00015
Cited by 15
AI Summary: OriGene products contributed to this study by providing the mouse DISC1 shRNA (OriGene, TG502070) used for RNAi-mediated knockdown of DISC1, enabling the authors to investigate the role of DISC1 in synaptic vesicle exocytosis.
Disrupted-in-Schizophrenia-1 Attenuates Amyloid-β Generation and Cognitive Deficits in APP/PS1 Transgenic Mice by Reduction of β-Site APP-Cleaving Enzyme 1 Levels
Deng, Dong, Wu et al
Neuropsychopharmacology (2016) 41 (2), 440-53 DOI: 10.1038/npp.2015.164
Deng, Dong, Wu et al
Neuropsychopharmacology (2016) 41 (2), 440-53 DOI: 10.1038/npp.2015.164
AI Summary: OriGene's purified recombinant DISC1 protein (transcript variant L) was used in this study to investigate the molecular mechanisms by which DISC1 regulates BACE1 levels and amyloid-β generation in Alzheimer's disease models.
Snippet: BACE1 intracellular domain (a.a. 478–501) peptide was synthesized by China peptides Company (Shanghai, China). Purified recombinant DISC1 protein (transcript variant L) was purchased from Origene (Rockville, MD)
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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